Putting the brakes on the anti-viral response: negative regulators of type I interferon (IFN) production

被引：51

作者：

Richards, Kathryn H. ^{[1
]}

Macdonald, Andrew ^{[1
]}

机构：

[1] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

来源：

MICROBES AND INFECTION | 2011年 / 13卷 / 04期

关键词：

Interferon; Virus; Negative regulation; TOLL-LIKE RECEPTOR; NF-KAPPA-B; TUMOR-SUPPRESSOR CYLD; RIG-I; SIGNALING PATHWAY; GENE-EXPRESSION; BETA PRODUCTION; FEEDBACK-REGULATION; IMMUNE-RESPONSES; IKK-EPSILON;

D O I：

10.1016/j.micinf.2010.12.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Type I IFNs (IFN alpha/beta) are essential anti-viral cytokines produced in response to the detection of viral components by host pattern recognition receptors. IFN alpha/beta production is transient, and aberrant activation can be hazardous to the host. In this article, we review our current understanding of host negative regulatory mechanisms that control IFN alpha/beta production. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：291 / 302

页数：12

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