Heritability of BMD of femoral neck and lumbar spine:: A multivariate twin study of Finnish men

被引:52
作者
Videman, Tapio
Levaelahti, Esko
Batti, Michele C.
Simonen, Riitta
Vanninen, Esko
Kaprio, Jaakko
机构
[1] Univ Alberta, Fac Rehabil Med, Edmonton, AB T6G 2G4, Canada
[2] Univ Helsinki, Finnish Twin Cohort Study, Helsinki, Finland
[3] Univ Kuopio, Kuopio Univ Hosp, FIN-70211 Kuopio, Finland
关键词
exercise; genetic research; osteoporosis; mechanical loading; muscle; twins;
D O I
10.1359/JBMR.070606
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Of the 80% variation in BMD among male twins that is caused by genetics, part was explained by genetic influences on lifting strength and lean body mass/height. Lifting strength was significant in both the femoral and spine BMD and body weight only for lumbar BMD.
引用
收藏
页码:1455 / 1462
页数:8
相关论文
共 43 条
[1]
Genetic influences on muscle strength, lean body mass, and bone mineral density: A twin study [J].
Arden, NK ;
Spector, TD .
JOURNAL OF BONE AND MINERAL RESEARCH, 1997, 12 (12) :2076-2081
[2]
Determinants of lumbar disc degeneration - A study relating lifetime exposures and magnetic resonance imaging findings in identical twins [J].
Battie, MC ;
Videman, T ;
Gibbons, LE ;
Fisher, LD ;
Manninen, H ;
Gill, K .
SPINE, 1995, 20 (24) :2601-2612
[3]
Genetic determinants of sports participation and daily physical activity [J].
Beunen, G ;
Thomis, M .
INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (Suppl 3) :S55-S63
[4]
BOUCHARD C, 1988, INT J OBESITY, V12, P205
[5]
CHRISTIAN JC, 1989, AM J HUM GENET, V44, P429
[6]
Cooper GS, 1996, J BONE MINER RES, V11, P1841
[7]
[9]
Evidence for a major gene for bone mineral density/content in human pedigrees identified via probands with extreme bone mineral density [J].
Deng, HW ;
Livshits, G ;
Yakovenko, K ;
Xu, FH ;
Conway, T ;
Davies, KM ;
Deng, H ;
Recker, RR .
ANNALS OF HUMAN GENETICS, 2002, 66 :61-74
[10]
GENETIC-DETERMINANTS OF BONE-MINERAL CONTENT AT THE SPINE AND RADIUS - A TWIN STUDY [J].
DEQUEKER, J ;
NIJS, J ;
VERSTRAETEN, A ;
GEUSENS, P ;
GEVERS, G .
BONE, 1987, 8 (04) :207-209