Prepro-galanin messenger RNA levels are increased in rat locus coeruleus after treadmill exercise training

被引：42

作者：

O'Neal, HA

Van Hoomissen, JD

Holmes, PV

Dishman, RK ^{[1
]}

机构：

[1] Univ Georgia, Dept Exercise Sci, Athens, GA 30602 USA

[2] Univ Georgia, Dept Psychol, Athens, GA 30602 USA

来源：

NEUROSCIENCE LETTERS | 2001年 / 299卷 / 1-2期

关键词：

in situ hybridization; neuropeptides; physical activity; tyrosine hydroxylase; stress;

D O I：

10.1016/S0304-3940(00)01780-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of treadmill exercise training on prepro-galanin (GAL) and tyrosine hydroxylase (TH) gene expression in the locus coeruleus (LC) were examined. Male Fischer-344 rats (n = 9) were assigned to 6 weeks of treadmill running. An additional group of animals comprised the sedentary home cage control group (n = 9). Levels of GAL and TH messenger RNA (mRNA) in the LC were measured using in situ hybridization histochemistry with autoradiography. Levels of GAL mRNA were higher in treadmill trained animals compared to sedentary animals, but there was no effect of treadmill running on TH mRNA. These results suggest that gene expression for galanin is responsive to repeated exercise stress and may have a neuromodulatory role in LC-noradrenergic adaptation to treadmill exercise training. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：69 / 72

页数：4

共 23 条

[21] Tyrosine hydroxylase gene expression in the locus coeruleus of depression-model rats and rats exposed to short- and long-term forced walking stress [J].