Relation of albumin/creatinine ratio to C-reactive protein and to the metabolic syndrome

被引：17

作者：

Messerli, AW ^{[1
]}

Seshadri, N ^{[1
]}

Pearce, GL ^{[1
]}

Sachar, R ^{[1
]}

Hoogwerf, BJ ^{[1
]}

Sprecher, DL ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Dept Prevent Cardiovasc Med, Cleveland, OH 44195 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2003年 / 92卷 / 05期

关键词：

D O I：

10.1016/S0002-9149(03)00736-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We hypothesized that-the association of high sensitivity C-reactive protein (CRP) with urinary albumin excretion (UAE) is predominately mediated through its correlation with the metabolic syndrome. Serum CRP and urine albumin:creatinine ratios (ACR) from 720 preventive cardiology patients were analyzed to estimate age- and gender-adjusted relative risk of high CRP and metabolic syndrome for high ACR. These data demonstrate that CRP independently predicts the presence of UAE, a marker of endothelial dysfunction. (C) 2003 by Excerpta Medical, Inc.

引用

页码：610 / 612

页数：3

共 20 条

[1]

[Anonymous], 2001, JAMA-J AM MED ASSOC, V285, P2846

[2] Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity [J].

Arcaro, G ;

Zamboni, M ;

Rossi, L ;

Turcato, E ;

Covi, G ;

Armellini, F ;

Bosello, O ;

Lechi, A .

INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (09) :936-942

[3] Endothelial dysfunction is detectable in young normotensive first-degree relatives of subjects with type 2 diabetes in association with insulin resistance [J].

Balletshofer, BM ;

Rittig, K ;

Enderle, MD ;

Volk, A ;

Maerker, E ;

Jacob, S ;

Matthaei, S ;

Rett, K ;

Häring, HU .

CIRCULATION, 2000, 101 (15) :1780-1784

[4] Interleukin-6 is an essential, corticotropin-releasing hormone-independent stimulator of the adrenal axis during immune system activation [J].

Bethin, KE ;

Vogt, SK ;

Muglia, LJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :9317-9322

[5] Novel clinical markers of vascular wall inflammation [J].

Blake, GJ ;

Ridker, PM .

CIRCULATION RESEARCH, 2001, 89 (09) :763-771

[6] INTERLEUKIN-6 IS THE MAJOR REGULATOR OF ACUTE PHASE PROTEIN-SYNTHESIS IN ADULT HUMAN HEPATOCYTES [J].

CASTELL, JV ;

GOMEZLECHON, MJ ;

DAVID, M ;

ANDUS, T ;

GEIGER, T ;

TRULLENQUE, R ;

FABRA, R ;

HEINRICH, PC .

FEBS LETTERS, 1989, 242 (02) :237-239

[7] Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease [J].

Cleland, SJ ;

Sattar, N ;

Petrie, JR ;

Forouhi, NG ;

Elliott, HL ;

Connell, JMC .

CLINICAL SCIENCE, 2000, 98 (05) :531-535

[8]

Feldt-Rasmussen B, 2000, DIABETES METAB, V26, P64

[9] Inflammation and microalbuminuria in nondiabetic and type 2 diabetic subjects:: The Insulin Resistance Atherosclerosis Study [J].

Festa, A ;

D'Agostino, R ;

Howard, G ;

Mykkänen, L ;

Tracy, RP ;

Haffner, SM .

KIDNEY INTERNATIONAL, 2000, 58 (04) :1703-1710

[10] Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease [J].

Fichtlscherer, S ;

Rosenberger, G ;

Walter, DH ;

Breuer, S ;

Dimmeler, S ;

Zeiher, AM .

CIRCULATION, 2000, 102 (09) :1000-1006

← 1 2 →