A highly efficient synthesis of rocaglaols by a novel α-arylation of ketones

被引：29

作者：

Diedrichs, N ^{[1
]}

Ragot, JP ^{[1
]}

Thede, K ^{[1
]}

机构：

[1] Bayer HealthCare, Div Pharma, D-42096 Wuppertal, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 09期

关键词：

alpha-arylation of ketones; drug design; natural products; Suzuki reaction; total synthesis;

D O I：

10.1002/ejoc.200400891

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rocaglaols are natural products exhibiting a range of biological activities. A new synthetic method for the alpha-arylation of ketones allows for the synthesis of previously inaccessible rocaglaol derivatives. The key sequence consists of a previously unreported Suzuki type reaction using brominated silyl enol ethers as substrates followed by deprotection of the arylated silyl enol ethers. ((c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).

引用

页码：1731 / 1735

页数：5

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