Replication checkpoint: Preventing mitotic catastrophe

被引：64

作者：

Canman, CE ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Memphis, TN 38105 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 04期

关键词：

D O I：

10.1016/S0960-9822(01)00057-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A conserved network of signal transduction pathways prevents mitosis if DNA is damaged or its synthesis incomplete. Loss of this checkpoint control is detrimental to the developing embryo. Recent studies have shed new light on how the essential ATR and Chk1 protein kinases cooperate to prevent such a crisis.

引用

页码：R121 / R124

页数：4

共 29 条

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