Minimising Research Bottlenecks by Decluttering NMR Spectra

被引:24
作者
Aguilar, Juan A. [1 ,2 ]
Cassani, Julia [3 ]
Delbianco, Martina [1 ]
Adams, Ralph W. [2 ]
Nilsson, Mathias [2 ]
Morris, Gareth A. [2 ]
机构
[1] Univ Durham, Dept Chem, Durham DH1 3LE, England
[2] Univ Manchester, Sch Chem, Manchester M13 9PL, Lancs, England
[3] Univ Autonoma Metropolitana Unidad, Dept Sistemas Biol, Col Villa Quietud 04960, DF, Mexico
关键词
isomers; NMR spectroscopy; pure shift; structure elucidation; PURE SHIFT H-1-NMR; PARA-HYDROGEN; RESOLUTION; SENSITIVITY; ENANTIODIFFERENTIATION; SPECTROSCOPY; H-1;
D O I
10.1002/chem.201406283
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The lack of resolving power in everyday NMR produces ambiguous data, causing bottlenecks, lengthening multi-step projects and increasing the likelihood of making mistakes. Significant impacts can be made in many fields by minimising these problems with the aid of pure shift techniques.
引用
收藏
页码:6623 / 6630
页数:8
相关论文
共 43 条
[1]   Reversible Interactions with para-Hydrogen Enhance NMR Sensitivity by Polarization Transfer [J].
Adams, Ralph W. ;
Aguilar, Juan A. ;
Atkinson, Kevin D. ;
Cowley, Michael J. ;
Elliott, Paul I. P. ;
Duckett, Simon B. ;
Green, Gary G. R. ;
Khazal, Iman G. ;
Lopez-Serrano, Joaqun ;
Williamson, David C. .
SCIENCE, 2009, 323 (5922) :1708-1711
[2]   "Pure shift" 1H NMR, a robust method for revealing heteronuclear couplings in complex spectra [J].
Aguilar, Juan A. ;
Morris, Gareth A. ;
Kenwright, Alan M. .
RSC ADVANCES, 2014, 4 (16) :8278-8282
[3]   Simple Proton Spectra from Complex Spin Systems: Pure Shift NMR Spectroscopy Using BIRD [J].
Aguilar, Juan A. ;
Nilsson, Mathias ;
Morris, Gareth A. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (41) :9716-9717
[4]   Pure Shift 1H NMR: A Resolution of the Resolution Problem? [J].
Aguilar, Juan A. ;
Faulkner, Stephen ;
Nilsson, Mathias ;
Morris, Gareth A. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 49 (23) :3901-3903
[5]  
[Anonymous], 2013, ANGEW CHEM, V125, P11830
[6]  
[Anonymous], 2010, ANGEW CHEM, V122, P3993
[7]  
[Anonymous], 2003, ANGEW CHEM, V115, P4068
[8]  
[Anonymous], 2011, ANGEW CHEM, V123, P9890
[9]  
[Anonymous], 2013, ANGEW CHEM, V125, P7283
[10]   Increase in signal-to-noise ratio of >10,000 times in liquid-state NMR [J].
Ardenkjaer-Larsen, JH ;
Fridlund, B ;
Gram, A ;
Hansson, G ;
Hansson, L ;
Lerche, MH ;
Servin, R ;
Thaning, M ;
Golman, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (18) :10158-10163