Multicolor In Vivo Imaging of Upconversion Nanopaticles with Emissions Tuned by Luminescence Resonance Energy Transfer

被引：141

作者：

Cheng, Liang ^{[1
]}

Yang, Kai ^{[1
]}

Shao, Mingwang ^{[1
]}

Lee, Shuit-Tong ^{[2
,3
]}

Liu, Zhuang ^{[1
]}

机构：

[1] Soochow Univ, Inst Funct Nano & Soft Mat, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[2] City Univ Hong Kong, COSDAF, Hong Kong, Hong Kong, Peoples R China

[3] City Univ Hong Kong, Dept Phys & Mat Sci, Hong Kong, Hong Kong, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2011年 / 115卷 / 06期

基金：

中国国家自然科学基金;

关键词：

QUANTUM DOTS; NANOCRYSTALS;

D O I：

10.1021/jp111006z

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Upconversion nanoparticles (UCNPs) based on sodium yttrium fluoride (NaYF4) nanocrystals are synthesized, functionalized with an amphiphilic polymer, and loaded with fluorescent and quenching molecules by physical adsorption. The formed supramolecular UCNP-dye complexes show tuned visible emission spectra owing to the luminescence resonance energy transfer (LRET) from nanoparticles to the organic dyes under near-infrared (NIR) excitation, and can be well separated in multicolor imaging after spectral decovolution. Our work provides a facile and flexible method to modulate the upconversion luminescence (UCL) spectra of UCNPs for in vivo multicolor UCL imaging in animals.

引用

页码：2686 / 2692

页数：7

共 35 条

[1] AUTOFLUORESCENCE OF VIABLE CULTURED MAMMALIAN-CELLS [J].