The mannose receptor: linking homeostasis and immunity through sugar recognition

被引：270

作者：

Taylor, PR ^{[1
]}

Gordon, S ^{[1
]}

Martinez-Pomares, L ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 02期

关键词：

D O I：

10.1016/j.it.2004.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The mannose receptor (MR) can potentially internalize compounds that are recognized by three binding sites located in its extracellular region. It is subject to proteolytic processing and glycosylation, has a complex expression pattern and exhibits tissue-dependent binding properties. It is not surprising, given this complexity, that the MR has been implicated in homeostatic processes, such as clearance of endogenous products and cell adhesion, as well as pathogen recognition and antigen presentation. In this Review, we summarize the current knowledge regarding the different aspects of MR binding properties, contribution to homeostatic clearance, cell activation and antigen presentation.

引用

页码：104 / 110

页数：7

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