Clonal distribution and phase-variable expression of a major histocompatibility complex analogue protein in Staphylococcus aureus

被引:13
作者
Buckling, A
Neilson, J
Lindsay, J
ffrench-Constant, R
Enright, M
Day, N
Massey, RC
机构
[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
[2] Univ Bath, Dept Biol & Biochem, Bath BA2 7AY, Avon, England
[3] St Georges Med Sch, London, England
[4] Mahidol Univ, Fac Trop Med, Bangkok, Thailand
关键词
D O I
10.1128/JB.187.8.2917-2919.2005
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学]; 100705 [微生物与生化药学];
摘要
The mapW gene of Staphylococcus aureus strain N315 contains a polly(A) tract which truncates translation of the protein. This study demonstrates that mapW is an allelic variant of the map/eap genes found in other strains and that the variation in the length of this poly(A) tract suggests that it is a contingency locus.
引用
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页码:2917 / 2919
页数:3
相关论文
共 15 条
[1]
Crawley MJ., 1993, GLIM ECOLOGISTS
[2]
AN OVERVIEW OF NOSOCOMIAL INFECTIONS, INCLUDING THE ROLE OF THE MICROBIOLOGY LABORATORY [J].
EMORI, TG ;
GAYNES, RP .
CLINICAL MICROBIOLOGY REVIEWS, 1993, 6 (04) :428-442
[3]
How clonal is Staphylococcus aureus? [J].
Feil, EJ ;
Cooper, JE ;
Grundmann, H ;
Robinson, DA ;
Enright, MC ;
Berendt, T ;
Peacock, SJ ;
Smith, JM ;
Murphy, M ;
Spratt, BG ;
Moore, CE ;
Day, NPJ .
JOURNAL OF BACTERIOLOGY, 2003, 185 (11) :3307-3316
[4]
The adhesive and immunomodulating properties of the multifunctional Staphylococcus aureus protein Eap [J].
Harraghy, N ;
Hussain, M ;
Haggar, A ;
Chavakis, T ;
Sinha, B ;
Herrmann, M ;
Flock, JI .
MICROBIOLOGY-SGM, 2003, 149 :2701-2707
[5]
Molecular switches - the ON and OFF of bacterial phase variation [J].
Henderson, IR ;
Owen, P ;
Nataro, JP .
MOLECULAR MICROBIOLOGY, 1999, 33 (05) :919-932
[6]
Complete genomes of two clinical Staphylococcus aureus strains:: Evidence for the rapid evolution of virulence and drug resistance [J].
Holden, MTG ;
Feil, EJ ;
Lindsay, JA ;
Peacock, SJ ;
Day, NPJ ;
Enright, MC ;
Foster, TJ ;
Moore, CE ;
Hurst, L ;
Atkin, R ;
Barron, A ;
Bason, N ;
Bentley, SD ;
Chillingworth, C ;
Chillingworth, T ;
Churcher, C ;
Clark, L ;
Corton, C ;
Cronin, A ;
Doggett, J ;
Dowd, L ;
Feltwell, T ;
Hance, Z ;
Harris, B ;
Hauser, H ;
Holroyd, S ;
Jagels, K ;
James, KD ;
Lennard, N ;
Line, A ;
Mayes, R ;
Moule, S ;
Mungall, K ;
Ormond, D ;
Quail, MA ;
Rabbinowitsch, E ;
Rutherford, K ;
Sanders, M ;
Sharp, S ;
Simmonds, M ;
Stevens, K ;
Whitehead, S ;
Barrell, BG ;
Spratt, BG ;
Parkhill, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (26) :9786-9791
[7]
Analogs of EAP protein are conserved and prevalent in clinical Staphylococcus aureus isolates [J].
Hussain, M ;
Becker, K ;
von Eiff, C ;
Peters, G ;
Herrmann, M .
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2001, 8 (06) :1271-1276
[8]
STAPHYLOCOCCUS-AUREUS EXPRESSES A MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II ANALOG [J].
JONSSON, K ;
MCDEVITT, D ;
MCGAVIN, MH ;
PATTI, JM ;
HOOK, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (37) :21457-21460
[9]
Whole genome sequencing of meticillin-resistant Staphylococcus aureus [J].
Kuroda, M ;
Ohta, T ;
Uchiyama, I ;
Baba, T ;
Yuzawa, H ;
Kobayashi, I ;
Cui, LZ ;
Oguchi, A ;
Aoki, K ;
Nagai, Y ;
Lian, JQ ;
Ito, T ;
Kanamori, M ;
Matsumaru, H ;
Maruyama, A ;
Murakami, H ;
Hosoyama, A ;
Mizutani-Ui, Y ;
Takahashi, NK ;
Sawano, T ;
Inoue, R ;
Kaito, C ;
Sekimizu, K ;
Hirakawa, H ;
Kuhara, S ;
Goto, S ;
Yabuzaki, J ;
Kanehisa, M ;
Yamashita, A ;
Oshima, K ;
Furuya, K ;
Yoshino, C ;
Shiba, T ;
Hattori, M ;
Ogasawara, N ;
Hayashi, H ;
Hiramatsu, K .
LANCET, 2001, 357 (9264) :1225-1240
[10]
The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses [J].
Lee, LY ;
Miyamoto, YJ ;
McIntyre, BW ;
Höök, M ;
McCrea, KW ;
McDevitt, D ;
Brown, EL .
JOURNAL OF CLINICAL INVESTIGATION, 2002, 110 (10) :1461-1471