Noncovalent DNA-Binding Metallo-Supramolecular Cylinders Prevent DNA Transactions in vitro

被引：60

作者：

Ducani, Cosimo ^{[2
]}

Leczkowska, Anna ^{[2
]}

Hodges, Nikolas J. ^{[1
]}

Hannon, Michael J. ^{[2
]}

机构：

[1] Univ Birmingham Edgbaston, Biosci Sect, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham Edgbaston, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 47期

关键词：

cancer; helical structures; metallodrugs; PCR inhibition; supramolecular chemistry; METALLOSUPRAMOLECULAR CYLINDERS; RECOGNITION; JUNCTION;

D O I：

10.1002/anie.201004471

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supramolecular metal cylinders not only bind noncovalently to DNA inducing substantial coiling but are able to recognize specific DNA structures involved in biological processes as DNA replication. It is demonstrated that these molecules can inhibit the amplification of the DNA mediated by a Taq DNA polymerase and are even able to displace the enzyme from a double strand DNA (see scheme). © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：8942 / 8945

页数：4

共 35 条

[1]

[Anonymous], 2002, Oxidative Phosphorylation

[2]

Benedetti M., 2008, ANGEW CHEM, V120, P517

[3] Experimental evidence that a DNA polymerase can incorporate N7-platinated guanines to give platinated DNA [J].