Opioid poorly-responsive cancer pain. Part 2: Basic mechanisms that could shift dose response for analgesia

被引：48

作者：

Mercadante, S

Portenoy, RK

机构：

[1] La Maddalena Canc Ctr, Anesthesia & Intens Care Unit, I-90146 Palermo, Italy

[2] La Maddalena Canc Ctr, Pain Relief & Palliat Care Unit, I-90146 Palermo, Italy

[3] Soc Assistenza Malato Oncol Terminale, Home Palliat Care Program, Palermo, Italy

[4] Beth Israel Med Ctr, Dept Pain Med & Palliat Care, New York, NY 10003 USA

来源：

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT | 2001年 / 21卷 / 03期

关键词：

cancer pain; neuropathic pain; tolerance; hyperalgesia; opioids; NMDA receptors;

D O I：

10.1016/S0885-3924(00)00236-0

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Basic research in experimental pain models may illuminate the phenomenon of cancer pain that is poorly responsive to opioid drugs. Research findings can be valuable in formulating new strategies in clinical practice. This review evaluated experimental observations in terms of the events that occur in cancer patients receiving opioid therapy for pain. J Pain Symptom Manage 2001;21:255-264. (C) U.S. Cancer Pain Relief Committee, 2001.

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收藏

页码：255 / 264

页数：10

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