Evolutionary conservation between budding yeast and human kinetochores

被引：89

作者：

Kitagawa, K

Hieter, P

机构：

[1] St Jude Childrens Res Hosp, Dept Mol Pharmacol, Memphis, TN 38105 USA

[2] Univ British Columbia, Biotechnol Lab, Vancouver, BC V6T 1Z3, Canada

[3] Ctr Mol Med & Therapeut, Vancouver, BC V5Z 4H4, Canada

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 09期

关键词：

D O I：

10.1038/35089568

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accurate chromosome segregation during mitosis requires the correct assembly of kinetochores - complexes of centromeric DNA and proteins that link chromosomes to spindle microtubules. Studies on the kinetochore of the budding yeast Saccharomyces cerevisiae have revealed functionally novel components of the kinetochore and its regulatory complexes, some of which are highly conserved in humans.

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页码：678 / 687

页数：10

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