Expression of serine/threonine kinase receptors in traumatic brain injury

被引:59
作者
Lewen, A
Soderstrom, S
Hillered, L
Ebendal, T
机构
[1] UNIV UPPSALA HOSP,DEPT NEUROSURG,S-75185 UPPSALA,SWEDEN
[2] UNIV UPPSALA HOSP,DEPT CLIN CHEM,S-75185 UPPSALA,SWEDEN
[3] UNIV UPPSALA HOSP,DEPT DEV NEUROSCI,S-75185 UPPSALA,SWEDEN
[4] BIOMED CTR,S-75185 UPPSALA,SWEDEN
关键词
activin; ActR-1; ALK; BMPR-II; bone morphogenetic protein; in situ hybridization; mRNA; neuronal plasticity; osteogenic protein; rat; receptors; serine-threonine protein kinase receptors; transforming growth factor beta superfamily; traumatic brain injury;
D O I
10.1097/00001756-199701200-00020
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
THE aim of this study was to investigate the expression of serine/threonine kinase receptors in the brain following traumatic brain injury. We report here that, the recently cloned and characterized bone morphogenetic protein (BMP) receptor type II (BMPR-II) and the activin receptor type IA (ActR-1) Act: mRNAs were simultaneously up-regulated in neurones in the dentate gyrus 6 h after a mild cerebral contusion injury. This finding was specific for these receptors since other investigated genes (i.e. ActR-II; ActR-IB, trkB and c-fos) showed other temporal patterns. These data suggest that type I and type II receptors act together in signal transduction in vivo and that BMPs may be involved in neuronal plasticity after traumatic brain injury.
引用
收藏
页码:475 / 479
页数:5
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