Expression of serine/threonine kinase receptors in traumatic brain injury

被引：59

作者：

Lewen, A

Soderstrom, S

Hillered, L

Ebendal, T

机构：

[1] UNIV UPPSALA HOSP,DEPT NEUROSURG,S-75185 UPPSALA,SWEDEN

[2] UNIV UPPSALA HOSP,DEPT CLIN CHEM,S-75185 UPPSALA,SWEDEN

[3] UNIV UPPSALA HOSP,DEPT DEV NEUROSCI,S-75185 UPPSALA,SWEDEN

[4] BIOMED CTR,S-75185 UPPSALA,SWEDEN

来源：

NEUROREPORT | 1997年 / 8卷 / 02期

关键词：

activin; ActR-1; ALK; BMPR-II; bone morphogenetic protein; in situ hybridization; mRNA; neuronal plasticity; osteogenic protein; rat; receptors; serine-threonine protein kinase receptors; transforming growth factor beta superfamily; traumatic brain injury;

D O I：

10.1097/00001756-199701200-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE aim of this study was to investigate the expression of serine/threonine kinase receptors in the brain following traumatic brain injury. We report here that, the recently cloned and characterized bone morphogenetic protein (BMP) receptor type II (BMPR-II) and the activin receptor type IA (ActR-1) Act: mRNAs were simultaneously up-regulated in neurones in the dentate gyrus 6 h after a mild cerebral contusion injury. This finding was specific for these receptors since other investigated genes (i.e. ActR-II; ActR-IB, trkB and c-fos) showed other temporal patterns. These data suggest that type I and type II receptors act together in signal transduction in vivo and that BMPs may be involved in neuronal plasticity after traumatic brain injury.

引用

页码：475 / 479

页数：5

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[21] CHANGES IN CORTICAL EXTRACELLULAR LEVELS OF ENERGY-RELATED METABOLITES AND AMINO-ACIDS FOLLOWING CONCUSSIVE BRAIN INJURY IN RATS [J].