Self-assembled monolayer coating for normalization of surface enhanced Raman spectra

被引：14

作者：

Lorén, A

Engelbrektsson, J

Eliasson, C

Josefson, M

Abrahamsson, J

Abrahamsson, K ^{[1
]}

机构：

[1] Chalmers Univ Technol, Dept Chem & Biosci, SE-41296 Gothenburg, Sweden

[2] AstraZeneca, Pharmaceut Analyt R&D, SE-41383 Molndal, Sweden

[3] Gothenburg Univ, Sahlgrenska Hosp, Dept Paediat, SE-41685 Gothenburg, Sweden

来源：

NANO LETTERS | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1021/nl035064x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We demonstrate that the use of a self-assembled monolayer, consisting of a thiol derivative of Dabcyl, can be used to normalize surface enhanced Raman signals (SERS) with respect to varying enhancement. Chaotic assemblies of gold nanoparticles exhibit large spatial variation in enhancement. Our work shows that in such a system the signals from the reporting molecules in the SAM co-vary with the signal from the analyte solution. With this knowledge, a normalization procedure was used to increase the precision of the analyte signal by 1 order of magnitude, to 8-13%, fully acceptable for quantitative work.

引用

页码：309 / 312

页数：4

共 28 条

[1]

ABRAHAM U, 1998, SELF ASSEMBLED MONOL

[2] Capacitance measurements of antibody-antigen interactions in a flow system [J].