Immunotoxins and other conjugates: Pre-clinical studies

被引：52

作者：

Bolognesi, A ^{[1
]}

Polito, L ^{[1
]}

机构：

[1] Univ Bologna, Dept Expt Pathol, I-40126 Bologna, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2004年 / 4卷 / 05期

关键词：

ribosome-inactivating proteins; toxins; conjugates; immunotoxins; targeting; immunotherapy;

D O I：

10.2174/1389557043403864

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A wide variety of conjugates containing RIPs, of either chemical or recombinant type, have been made and tested against dangerous cells in vitro and in animal models. Many of these pre-clinical studies will be reviewed here dividing them on the basis of the target cell and the surface molecule specifically recognized.

引用

页码：563 / 583

页数：21

共 234 条

[81] Conjugation of blocked ricin to an anti-CD19 monoclonal antibody increases antibody-induced cell calcium mobilization and CD19 internalization [J].

Goulet, AC ;

Goldmacher, VS ;

Lambert, JM ;

Baron, C ;

Roy, DC ;

Kouassi, E .

BLOOD, 1997, 90 (06) :2364-2375

[82] COMBINED ANTITUMOR THERAPY WITH THE CHEMOTHERAPEUTIC DRUG DOXORUBICIN AND AN ANTITRANSFERRIN RECEPTOR IMMUNOTOXIN - INVITRO AND INVIVO STUDIES [J].

GRIFFIN, TW ;

STOCL, M ;

COLLINS, J ;

FERNANDES, J ;

MAHER, VE .

JOURNAL OF IMMUNOTHERAPY, 1992, 11 (01) :12-18

[83]

GRIFFIN TW, 1987, CANCER RES, V47, P4266

[84]

GROSSBARD ML, 1992, CANCER RES, V52, P4200

[85] Toxicity profile of the investigational new biotherapeutic agent, B43 (anti-CD19)-pokeweed antiviral protein immunotoxin [J].

Gunther, R ;

Chelstrom, LM ;

Wendorf, HR ;

Schneider, EA ;

Covalciuc, K ;

Johnson, B ;

Clementson, D ;

Irvin, JD ;

Myers, DE ;

Uckun, FM .

LEUKEMIA & LYMPHOMA, 1996, 22 (1-2) :61-+

[86]

GUNTHER R, 1993, LEUKEMIA, V7, P298

[87] BIOTHERAPY FOR XENOGRAFTED HUMAN CENTRAL-NERVOUS-SYSTEM LEUKEMIA IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY USING B43 (ANTI-CD19)-POKEWEED ANTIVIRAL PROTEIN IMMUNOTOXIN [J].

GUNTHER, R ;

CHELSTROM, LM ;

TUELAHLGREN, L ;

SIMON, J ;

MYERS, DE ;

UCKUN, FM .

BLOOD, 1995, 85 (09) :2537-2545

[88] Clearance of antitransferrin receptor immunotoxin from the rabbit eye [J].

Handa, JT ;

Pearson, PA ;

Jaffe, GJ .

CURRENT EYE RESEARCH, 1996, 15 (10) :1039-1044

[89] Transferrin-ricin a chain toxin limits the development of experimental proliferative vitreoretinopathy [J].

Handa, JT ;

Keithahn, MA ;

Jaffe, GJ .

EXPERIMENTAL EYE RESEARCH, 1996, 62 (06) :689-695

[90]

HARKONEN S, 1987, CANCER RES, V47, P1377

← 4 5 6 7 8 9 10 11 12 13 →