Formation of β-glucosamine and β-mannose linkages using glycosyl phosphates

被引：24

作者：

Plante, OJ ^{[1
]}

Palmacci, ER ^{[1
]}

Seeberger, PH ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 24期

关键词：

D O I：

10.1021/ol006566+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Glycosyl phosphates were examined for their utility in the synthesis of challenging glycosidic linkages. beta -Glucosamine glycosides were formed preferentially and in good yield. beta -Mannosides were constructed in high overall yield with modest anomeric selectivity. Interesting solvent and conformational influences on the stereochemical outcome of the coupling reactions were observed.

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页码：3841 / 3843

页数：3

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