Structure and dynamics of ribosomal RNA

被引:18
作者
Woodson, SA [1 ]
Leontis, NB
机构
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Bowling Green State Univ, Dept Chem, Bowling Green, OH 43403 USA
关键词
D O I
10.1016/S0959-440X(98)80061-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Over the past two years, progress in X-ray crystallography, NMR spectroscopy and electron microscopy has begun to reveal the complex structure of the RNA within the ribosome. The structures of ribosomal proteins L11 and S15, among others, show how RNA-protein interactions organize the conformation of the junctions between ribosomal RNA helices. Genetic and biochemical methods have also identified a three base-pair switch within the 16S rRNA that is linked to mRNA decoding.
引用
收藏
页码:294 / 300
页数:7
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共 54 条
  • [1] Direct visualization of A-, P-, and E-site transfer RNAs in the Escherichia coli ribosome
    Agrawal, RK
    Penczek, P
    Grassucci, RA
    Li, YH
    Leith, A
    Nierhaus, KH
    Frank, J
    [J]. SCIENCE, 1996, 271 (5251) : 1000 - 1002
  • [2] A new technique for the characterization of long-range tertiary contacts in large RNA molecules: Insertion of a photolabel at a selected position in 16S rRNA within the Escherichia coli ribosome
    Baranov, PV
    Dokudovskaya, SS
    Oretskaya, TS
    Dontsova, OA
    Bogdanov, AA
    Brimacombe, R
    [J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (12) : 2266 - 2273
  • [3] Interaction of the Bacillus stearothermophilus ribosomal protein S15 with 16 S rRNA .2. Specificity determinants of RNA-protein recognition
    Batey, RT
    Williamson, JR
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1996, 261 (04) : 550 - 567
  • [4] Interaction of the Bacillus stearothermophilus ribosomal protein S15 with 16 S rRNA .1. Defining the minimal RNA site
    Batey, RT
    Williamson, JR
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1996, 261 (04) : 536 - 549
  • [5] Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus
    Berglund, H
    Rak, A
    Serganov, A
    Garber, M
    Hard, T
    [J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (01) : 20 - 23
  • [6] The solution structure of the S1 RNA binding domain: A member of an ancient nucleic acid-binding fold
    Bycroft, M
    Hubbard, TJP
    Proctor, M
    Freund, SMV
    Murzin, AG
    [J]. CELL, 1997, 88 (02) : 235 - 242
  • [7] Crystal structure of a group I ribozyme domain: Principles of RNA packing
    Cate, JH
    Gooding, AR
    Podell, E
    Zhou, KH
    Golden, BL
    Kundrot, CE
    Cech, TR
    Doudna, JA
    [J]. SCIENCE, 1996, 273 (5282) : 1678 - 1685
  • [8] CO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE-H5
    CLARK, KL
    HALAY, ED
    LAI, ES
    BURLEY, SK
    [J]. NATURE, 1993, 364 (6436) : 412 - 420
  • [9] Use of chemically modified nucleotides to determine a 62-nucleotide RNA crystal structure: A survey of phosphorothioates, Br, Pt and Hg
    Correll, CC
    Freeborn, B
    Moore, PB
    Steitz, TA
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1997, 15 (02) : 165 - 172
  • [10] Metals, motifs, and recognition in the crystal structure of a 5S rRNA domain
    Correll, CC
    Freeborn, B
    Moore, PB
    Steitz, TA
    [J]. CELL, 1997, 91 (05) : 705 - 712