A critical appraisal of vitiligo etiologic theories.: Is melanocyte loss a melanocytorrhagy?

被引:199
作者
Gauthier, Y
Andre, MC
Taïeb, A
机构
[1] CHU Bordeaux, Serv Dermatol, Hop St Ander, F-33076 Bordeaux, France
[2] Univ V Segalen Bordeaux, INSERM, E 0217, Bordeaux, France
来源
PIGMENT CELL RESEARCH | 2003年 / 16卷 / 04期
关键词
vitiligo; pathophysiology; melanocyte; antioxidants; adhesion; dendricity; apoptosis;
D O I
10.1034/j.1600-0749.2003.00070.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Common generalized vitiligo is an acquired depigmenting disorder characterized by a chronic and progressive loss of melanocytes from the epidermis and follicular reservoir. However, the mechanism of melanocyte disappearance has never been clearly understood, and the intervention of cellular and humoral autoimmune phenomena as primary events remains unproven. In this review, is discussed the data supporting the major theories of vitiligo, namely melanocyte destruction (autoimmune, neural and impaired redox status) and melanocyte inhibition or defective adhesion. Based on recent morphologic findings in vivo supporting a chronic detachment and transepidermal loss of melanocytes in common generalized vitiligo, a new theory is suggested proposing melanocytorrhagy as the primary defect underlying melanocyte loss, integrating most of the possible triggering/precipitating/enhancing effects of other known factors.
引用
收藏
页码:322 / 332
页数:11
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