Increased circulating hepatocyte growth factor in the early stage of acute myocardial infarction

被引:94
作者
Matsumori, A
Furukawa, Y
Hashimoto, T
Ono, K
Shioi, T
Okada, M
Iwasaki, A
Nishio, R
Sasayama, S
机构
[1] KYOTO UNIV,DEPT CARDIOVASC MED,KYOTO 606,JAPAN
[2] IJINKAI TAKEDA GEN HOSP,KYOTO 60113,JAPAN
关键词
D O I
10.1006/bbrc.1996.0606
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We measured serum hepatocyte growth factor (HGF) in patients with acute myocardial infarction, angina pectoris, and other heart diseases. In patients with acute myocardial infarction, blood was collected at the time of admission. Serum HGF was elevated within 3 hours in 8 of 10 patients (80%) with acute myocardial infarction after onset of chest pain (9.4 +/- 3.2 ng/mL, mean +/- SEM, values in normal subjects <0.39 ng/mL). Mean value of serum HGF was 11.0 +/- 2.6 ng/mL (n = 11) in patients who admitted to the hospital between 6 and 9 hours and 13.1 +/- 5.7 ng/mL between 12 and 24 hours after onset. Elevated HGF levels were significantly more frequent than those of creatine kinase within 3 hours, and elevated levels correlated well with those of serum creatine kinase at 6-9 hours after onset of acute myocardial infarction. No increase in serum HGF value was found in patients with angina pectoris or other heart diseases. Thus, measurement of HGF is a sensitive method for early diagnosis of acute myocardial infarction. (C) 1996 Academic Press, Inc.
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收藏
页码:391 / 395
页数:5
相关论文
共 16 条
  • [1] BIOCHEMICAL MARKERS OF MYOCARDIAL INJURY - IS MB CREATINE-KINASE THE CHOICE FOR THE 1990S
    ADAMS, JE
    ABENDSCHEIN, DR
    JAFFE, AS
    [J]. CIRCULATION, 1993, 88 (02) : 750 - 763
  • [2] HEPATOCYTE GROWTH-FACTOR IS A POTENT ANGIOGENIC FACTOR WHICH STIMULATES ENDOTHELIAL-CELL MOTILITY AND GROWTH
    BUSSOLINO, F
    DIRENZO, MF
    ZICHE, M
    BOCCHIETTO, E
    OLIVERO, M
    NALDINI, L
    GAUDINO, G
    TAMAGNONE, L
    COFFER, A
    COMOGLIO, PM
    [J]. JOURNAL OF CELL BIOLOGY, 1992, 119 (03) : 629 - 641
  • [3] PURIFICATION OF SCATTER FACTOR, A FIBROBLAST-DERIVED BASIC-PROTEIN THAT MODULATES EPITHELIAL INTERACTIONS AND MOVEMENT
    GHERARDI, E
    GRAY, J
    STOKER, M
    PERRYMAN, M
    FURLONG, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) : 5844 - 5848
  • [4] SCATTER FACTOR INDUCES BLOOD-VESSEL FORMATION INVIVO
    GRANT, DS
    KLEINMAN, HK
    GOLDBERG, ID
    BHARGAVA, MM
    NICKOLOFF, BJ
    KINSELLA, JL
    POLVERINI, P
    ROSEN, EM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) : 1937 - 1941
  • [5] SERUM ENZYME ASSAYS IN THE DIAGNOSIS OF ACUTE MYOCARDIAL-INFARCTION - RECOMMENDATIONS BASED ON A QUANTITATIVE-ANALYSIS
    LEE, TH
    GOLDMAN, L
    [J]. ANNALS OF INTERNAL MEDICINE, 1986, 105 (02) : 221 - 231
  • [6] MATSUMORI A, 1994, BRIT HEART J, V72, P561
  • [7] MIYAZAWA K, 1993, J BIOL CHEM, V268, P10024
  • [8] IDENTIFICATION OF A FIBROBLAST-DERIVED EPITHELIAL MORPHOGEN AS HEPATOCYTE GROWTH-FACTOR
    MONTESANO, R
    MATSUMOTO, K
    NAKAMURA, T
    ORCI, L
    [J]. CELL, 1991, 67 (05) : 901 - 908
  • [9] MUTO Y, 1988, LANCET, V2, P72
  • [10] NAKAMURA T, 1991, Progress in Growth Factor Research, V3, P67, DOI 10.1016/0955-2235(91)90014-U