Gene regulation by Y-box proteins: coupling control of transcription and translation

被引：262

作者：

Matsumoto, K ^{[1
]}

Wolffe, AP ^{[1
]}

机构：

[1] NICHHD, Mol Embryol Lab, NIH, Bethesda, MD 20892 USA

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(98)01300-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Y-box proteins are multifunctional regulators of gene expression. In somatic cells, they have the capacity to exert positive and negative effects on both transcription and translation. In Xenopus oocytes, they help to mask maternal mRNA and couple the transcription of mRNA in the nucleus to its translational fate in the cytoplasm. This review describes how the capacity of the Y-box proteins to destabilize both RNA and DNA duplexes, together with their distribution between nuclear and cytoplasmic compartments, might explain these multiple roles.

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页码：318 / 323

页数：6

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