Ciprofloxacin-resistant, CTX-M-15-producing Escherichia coli ST131 clone in extraintestinal infections in Italy

被引：50

作者：

Cerquetti, M. ^{[1
]}

Giufre, M. ^{[1
]}

Garcia-Fernandez, A. ^{[1
]}

Accogli, M. ^{[1
]}

Fortini, D. ^{[1
]}

Luzzi, I. ^{[1
]}

Carattoli, A. ^{[1
]}

机构：

[1] Ist Super Sanita, Dept Infect Parasit & Immunomediated Dis, I-00161 Rome, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2010年 / 16卷 / 10期

关键词：

IncF plasmids; multidrug resistance; replicon typing; septicemia; ST131; urinary infections; QUINOLONE RESISTANCE; MULTIPLEX PCR; GENE; SALMONELLA; PREVALENCE; STRAINS;

D O I：

10.1111/j.1469-0691.2010.03162.x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Quinolone and beta-lactam resistance mechanisms and clonal relationships were characterized among Escherichia coli isolates resistant to ciprofloxacin and extended-spectrum cephalosporins associated with human extra-intestinal infections in Rome. The E. coli. ST131 clone was found to be prevalent. This clone invariably carried a specific pattern of substitutions in the topoisomerase genes and all isolates but one produced CTX-M-15. One ST131 isolate produced SHV-12. The new ST131 variant described here is of particular concern because it combines fluoroquinolone resistance and chromosomally encoded CTX-M-15.

引用

页码：1555 / 1558

页数：4

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