Preparation of biornimetic three-dimensional gelatin/montmorillonite-chitosan scaffold for tissue engineering

被引：98

作者：

Zheng, Jun Ping ^{[1
]}

Wang, Chuan Zeng ^{[1
]}

Wang, Xlu Xing ^{[1
]}

Wang, Hong Yan ^{[1
]}

Zhuang, Hong ^{[1
]}

De Yao, Kang ^{[1
]}

机构：

[1] Tianjin Univ, Dept Mat Sci & Engn, Tianjin 300072, Peoples R China

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2007年 / 67卷 / 09期

基金：

中国国家自然科学基金;

关键词：

gelatin; montmorillonite; chitosan; scaffold; properties; biocompatibility;

D O I：

10.1016/j.reactfunctpolym.2006.12.002

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A novel gelatin/montmorillonite-chitosan (Gel/MMT-CS) nanocomposite scaffold was prepared via the intercalation process and the freeze-drying technique, using the ice particulates as the porogen materials. Properties including pore structure, water adsorption content, in vitro degradation and tensile strength were investigated. It was demonstrated that the introduced intercalation structure endowed the Gel/MMT-CS scaffold with good mechanical properties and a controllable degradation rate. Scanning of the electron microscope images revealed that the scaffold obtained was highly 4 porous and suitable for the implanted cells to adhere and grow. The mitochondrial activity assay provided good evidences of cells viability on the Gel/MMT-CS membranes, giving an indication of possible application as a matrix for tissue engineering. (c) 2006 Published by Elsevier Ltd.

引用

页码：780 / 788

页数：9

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