Heart regeneration

被引：1047

作者：

Laflamme, Michael A. ^{[1
]}

Murry, Charles E. ^{[1
,2
,3
]}

机构：

[1] Univ Washington, Inst Stem Cell & Regenerat Med, Ctr Cardiovasc Biol, Dept Pathol, Seattle, WA 98109 USA

[2] Univ Washington, Inst Stem Cell & Regenerat Med, Ctr Cardiovasc Biol, Dept Bioengn, Seattle, WA 98109 USA

[3] Univ Washington, Inst Stem Cell & Regenerat Med, Ctr Cardiovasc Biol, Dept Med Cardiol, Seattle, WA 98109 USA

来源：

NATURE | 2011年 / 473卷 / 7347期

基金：

美国国家卫生研究院;

关键词：

EMBRYONIC STEM-CELLS; CARDIAC MYOCYTES; FUNCTIONAL CARDIOMYOCYTES; SMOOTH-MUSCLE; PLOIDY LEVEL; DNA-CONTENT; TRANSPLANTATION; THERAPY; DIFFERENTIATION; FIBROBLASTS;

D O I：

10.1038/nature10147

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Heart failure plagues industrialized nations, killing more people than any other disease. It usually results from a deficiency of specialized cardiac muscle cells known as cardiomyocytes, and a robust therapy to regenerate lost myocardium could help millions of patients every year. Heart regeneration is well documented in amphibia and fish and in developing mammals. After birth, however, human heart regeneration becomes limited to very slow cardiomyocyte replacement. Several experimental strategies to remuscularize the injured heart using adult stem cells and pluripotent stem cells, cellular reprogramming and tissue engineering are in progress. Although many challenges remain, these interventions may eventually lead to better approaches to treat or prevent heart failure.

引用

页码：326 / 335

页数：10

共 99 条

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[2]

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[3]

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