Concise Reviews: Characteristics and Potential Applications of Human Dental Tissue-Derived Mesenchymal Stem Cells

被引：329

作者：

Liu, Junjun ^{[1
]}

Yu, Fang ^{[3
]}

Sun, Yao ^{[3
]}

Jiang, Beizhan ^{[3
]}

Zhang, Wenjun ^{[2
]}

Yang, Jianhua ^{[1
]}

Xu, Guo-Tong

Liang, Aibin

Liu, Shangfeng

机构：

[1] Tongji Univ, Sch Med, Dept Ophthalmol, Shanghai Peoples Hosp 10, Shanghai 200092, Peoples R China

[2] Tongji Univ, Sch Med, Tongji Hosp, Translat Ctr Stem Cell Res, Shanghai 200092, Peoples R China

[3] Tongji Univ, Sch Stomatol, Lab Oral Biomed Sci & Translat Med, Shanghai 200092, Peoples R China

来源：

STEM CELLS | 2015年 / 33卷 / 03期

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

Mesenchymal stem cells; Dental stem cells; Tissue regeneration; Immunomodulation; Cell-based therapy; Dental stem cell banks; EXFOLIATED DECIDUOUS TEETH; MARROW STROMAL CELLS; ALVEOLAR BONE-MARROW; HUMAN TOOTH; IN-VITRO; IMMUNOMODULATORY PROPERTIES; STEM/PROGENITOR CELLS; APICAL PAPILLA; ODONTOGENIC DIFFERENTIATION; MULTILINEAGE CELLS;

D O I：

10.1002/stem.1909

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Recently, numerous types of human dental tissue-derived mesenchymal stem cells (MSCs) have been isolated and characterized, including dental pulp stem cells, stem cells from exfoliated deciduous teeth, periodontal ligament stem cells, dental follicle progenitor cells, alveolar bonederived MSCs, stem cells from apical papilla, tooth germ progenitor cells, and gingival MSCs. All these MSC-like cells exhibit self-renewal, multilineage differentiation potential, and immunomodulatory properties. Several studies have demonstrated the potential advantages of dental stem cell-based approaches for regenerative treatments and immunotherapies. This review outlines the properties of various dental MSC-like populations and the progress toward their use in regenerative therapy. Several dental stem cell banks worldwide are also introduced, with a view toward future clinical application.

引用

页码：627 / 638

页数：12

共 124 条

[1]

Multilineage Cells from Apical Pulp of Human Tooth with Immature Apex [J].