An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

被引：410

作者：

Zeller, KI

Jegga, AG

Aronow, BJ

O'Donnell, KA

Dang, CV ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Dept Med,Div Hematol, Baltimore, MD 21205 USA

[2] Childrens Hosp, Med Ctr, Childrens Hosp Res Fdn, Div Pediat Informat, Cincinnati, OH 45229 USA

[3] Childrens Hosp, Med Ctr, Childrens Hosp Res Fdn, Div Mol Dev Biol, Cincinnati, OH 45229 USA

[4] Univ Cincinnati, Dept Biomed Engn, Cincinnati, OH 45229 USA

[5] Johns Hopkins Univ, Sch Med, Program Human Genet & Mol Biol, Baltimore, MD 21205 USA

来源：

GENOME BIOLOGY | 2003年 / 4卷 / 10期

关键词：

D O I：

10.1186/gb-2003-4-10-r69

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report a database of genes responsive to the Myc oncogenic transcription factor. The database Myc Target Gene prioritizes candidate target genes according to experimental evidence and clusters responsive genes into functional groups. We coupled the prioritization of target genes with phylogenetic sequence comparisons to predict c-Myc target binding sites, which are in turn validated by chromatin immunoprecipitation assays. This database is essential for the understanding of the genetic regulatory networks underlying the genesis of cancers.

引用

页数：10

共 18 条

[1] BINDING OF MYC PROTEINS TO CANONICAL AND NONCANONICAL DNA-SEQUENCES
BLACKWELL, TK
HUANG, J
MA, A
KRETZNER, L
ALT, FW
EISENMAN, RN
WEINTRAUB, H
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (09) : 5216 - 5224
[2] c-Myc target gene specificity is determined by a post-DNA-binding mechanism
Boyd, KE
Wells, J
Gutman, J
Bartley, SM
Farnham, PJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13887 - 13892
[3] Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion
Coller, HA
Grandori, C
Tamayo, P
Colbert, T
Lander, ES
Eisenman, RN
Golub, TR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) : 3260 - 3265
[4] CHIMERAS OF MYC ONCOPROTEIN AND STEROID-RECEPTORS CAUSE HORMONE-DEPENDENT TRANSFORMATION OF CELLS
EILERS, M
PICARD, D
YAMAMOTO, KR
BISHOP, JM
[J]. NATURE, 1989, 340 (6228) : 66 - 68
[5] Genomic targets of the human c-Myc protein
Fernandez, PC
Frank, SR
Wang, LQ
Schroeder, M
Liu, SX
Greene, J
Cocito, A
Amati, B
[J]. GENES & DEVELOPMENT, 2003, 17 (09) : 1115 - 1129
[6] Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
Frank, SR
Schroeder, M
Fernandez, P
Taubert, S
Amati, B
[J]. GENES & DEVELOPMENT, 2001, 15 (16) : 2069 - 2082
[7] Cdc25 cell-cycle phosphatase as a target of c-myc
Galaktionov, K
Chen, XC
Beach, D
[J]. NATURE, 1996, 382 (6591) : 511 - 517
[8] Myc-Max heterodimers activate a DEAD box gene and interact with multiple E box-related sites in vivo
Grandori, C
Mac, J
Siebelt, F
Ayer, DE
Eisenman, RN
[J]. EMBO JOURNAL, 1996, 15 (16) : 4344 - 4357
[9] A strategy for identifying transcription factor binding sites reveals two classes of genornic c-Myc target sites
Haggerty, TJ
Zeller, KI
Osthus, RC
Wonsey, DR
Dang, CV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (09) : 5313 - 5318
[10] Detection and visualization of compositionally similar cis-regulatory element clusters in orthologous and coordinately controlled genes
Jegga, AG
Sherwood, SP
Carman, JW
Pinski, AT
Phillips, JL
Pestian, JP
Aronow, BJ
[J]. GENOME RESEARCH, 2002, 12 (09) : 1408 - 1417

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