Pharmacological inactivation of MYC for the treatment of cancer

被引:17
作者
Felsher, DW [1 ]
Bradon, N
机构
[1] Stanford Univ, Dept Med, Div Oncol, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Pathol, Div Oncol, Stanford, CA 94305 USA
关键词
CHRONIC MYELOID-LEUKEMIA; ABL TYROSINE KINASE; C-MYC; ANTISENSE OLIGONUCLEOTIDE; NEOPLASTIC PHENOTYPE; GENOMIC INSTABILITY; SMALL-MOLECULE; CELLS; INHIBITOR; TUMORIGENESIS;
D O I
10.1358/dnp.2003.16.6.829309
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The overexpression of the MYC proto-oncogene has been implicated in the pathogenesis of most types of human cancer. Recent experimental observations indicate that the inactivation of MYC may be effective in the treatment of neoplasia. Several different strategies have been employed to develop novel drugs that may be effective to target the inactivation of MYC for the treatment of cancer. Some of these strategies are discussed. (C) 2003 Prous Science. All rights reserved.
引用
收藏
页码:370 / 374
页数:5
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