Regulation of Na+ channel distribution in the nervous system

被引：60

作者：

Novakovic, SD ^{[1
]}

Eglen, RM

Hunter, JC

机构：

[1] Roche Biosci, Palo Alto, CA 94304 USA

[2] DiscoveRx Corp, Fremont, CA 94538 USA

[3] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 08期

关键词：

D O I：

10.1016/S0166-2236(00)01884-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.

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收藏

页码：473 / 478

页数：6

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