Regulation of Na+ channel distribution in the nervous system

被引:60
作者
Novakovic, SD [1 ]
Eglen, RM
Hunter, JC
机构
[1] Roche Biosci, Palo Alto, CA 94304 USA
[2] DiscoveRx Corp, Fremont, CA 94538 USA
[3] Schering Plough Corp, Res Inst, Kenilworth, NJ 07033 USA
关键词
D O I
10.1016/S0166-2236(00)01884-1
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.
引用
收藏
页码:473 / 478
页数:6
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