The cognitive neuroscience of schizophrenia

被引：280

作者：

Barch, Deanna M. ^{[1
]}

机构：

[1] Washington Univ, Dept Psychol, St Louis, MO 63130 USA

来源：

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY | 2005年 / 1卷

关键词：

working memory; episodic memory; prefrontal cortex; hippocampus; executive control;

D O I：

10.1146/annurev.clinpsy.1.102803.143959

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Individuals with schizophrenia experience a range of cognitive deficits and associated dysfunctions in the neural systems that support cognitive processes. This chapter reviews the literature on disturbances in working memory, executive control, and episodic memory in schizophrenia. Advances in basic cognitive neuroscience are described to help explain the cognitive neuroscience of schizophrenia. For working memory in schizophrenia, evidence is reviewed regarding deficits in the verbal (phonological loop) and nonverbal (visual-spatial scratch pad) buffer systems as well as in the central executive function. In the domain of episodic memory, evidence is reviewed for deficits in recollection versus familiarity processes in episodic memory. Also discussed are conceptual issues and potential confounds relevant to understanding the cognitive neuroscience of schizophrenia, including the role that cognitive deficits play in the developmental course of schizophrenia, relationships to specific symptom domains, behavioral performance confounds, and medication influences on behavioral performance and brain function.

引用

页码：321 / 353

页数：35

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