Translating molecular discoveries into new therapies for atherosclerosis

被引：394

作者：

Rader, Daniel J. ^{[1
,2
]}

Daugherty, Alan ^{[3
,4
]}

机构：

[1] Univ Penn, Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Inst Translat Med & Therapeut, Philadelphia, PA 19104 USA

[3] Univ Kentucky, Cardiovasc Res Ctr, Lexington, KY 40536 USA

[4] Univ Kentucky, Gill Heart Inst, Lexington, KY 40536 USA

来源：

NATURE | 2008年 / 451卷 / 7181期

关键词：

D O I：

10.1038/nature06796

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Atherosclerosis is characterized by the thickening of the arterial wall and is the primary cause of coronary artery disease and cerebrovascular disease, two of the most common causes of illness and death worldwide. Clinical trials have confirmed that certain lipoproteins and the renin-angiotensin-aldosterone system are important in the pathogenesis of atherosclerotic cardiovascular disease, and that interventions targeted towards these are beneficial. Furthermore, efforts to understand how risk factors such as high blood pressure, dysregulated blood lipids and diabetes contribute to atherosclerotic disease, as well as to understand the molecular pathogenesis of atherosclerotic plaques, are leading to new targets for therapy.

引用

页码：904 / 913

页数：10

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