Characteristics of complement activation in mice bearing Lewis lung carcinomas treated by photodynamic therapy

被引：56

作者：

Cecic, I

Serrano, K

Gyongyossy-Issa, M

Korbelik, M

机构：

[1] British Columbia Canc Agcy, British Columbia Canc Res Ctr, Dept Canc Imaging, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Canadian Blood Serv, Vancouver, BC V6T 2B5, Canada

来源：

CANCER LETTERS | 2005年 / 225卷 / 02期

关键词：

photodynamic therapy; complement system; C3; mouse LLC tumor model;

D O I：

10.1016/j.canlet.2004.11.059

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Following treatment of Lewis lung carcinomas (LLC) by Photofrin-mediated photodynamic therapy (PDT), tumor tissues and sera of host mice were collected for the analysis of complement activity. Elevated tumor C3 levels were detected between 1 and 24 h after PDT, while serum C3 levels increased significantly at 24 h post therapy. Increased alternative complement pathway activity in the serum was evident between 1 and 3 days post PDT. Blocking C3a- or C5a-receptors in the host mice decreased the efficacy of PDT in producing LLC tumor cures, supporting the importance of complement action in PDT-mediated tumor destruction. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：215 / 223

页数：9

共 38 条

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