The EuroPhysiome, STEP and a roadmap for the virtual physiological human

被引：80

作者：

Fenner, J. W. ^{[1
]}

Brook, B. ^{[2
]}

Clapworthy, G. ^{[3
]}

Coveney, P. V. ^{[4
]}

Feipel, V. ^{[5
]}

Gregersen, H. ^{[6
]}

Hose, D. R. ^{[1
]}

Kohl, P. ^{[7
]}

Lawford, P. ^{[1
]}

McCormack, K. M. ^{[1
]}

Pinney, D. ^{[1
]}

Thomas, S. R. ^{[8
]}

Jan, S. Van Sint ^{[5
]}

Waters, S. ^{[9
]}

Viceconti, M. ^{[10
]}

机构：

[1] Univ Sheffield, Royal Hallamshire Hosp, Dept Med Phys & Clin Engn, Sheffield S10 2JF, S Yorkshire, England

[2] Univ Nottingham, Div Appl Math, Nottingham NG7 2RD, England

[3] Univ Bedfordshire, Inst Res Applicable Comp, Luton LU1 3JU, Beds, England

[4] UCL, Ctr Computat Sci, London WC1H 0AJ, England

[5] Univ Libre Bruxelles, LABO, B-1070 Brussels, Belgium

[6] Aalborg Hosp, Sci & Innovat Ctr, Ctr Excellence Visceral Biomech & Pain, DK-9000 Aalborg, Denmark

[7] Univ Oxford, Cardiac Mech Elect Feedback Grp, Dept Physiol Anat & Genet, Oxford OX1 3PT, England

[8] CNRS, IBISC FRE 2873, F-91000 Evry, France

[9] Univ Oxford, Math Inst, Oxford OX1 3LB, England

[10] Ist Ortoped Rizzoli, Lab Tecnol Med, I-40136 Bologna, Italy

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES | 2008年 / 366卷 / 1878期

关键词：

physiome; EuroPhysiome; integrative biology; virtual physiological human; strategy for the EuroPhysiome;

D O I：

10.1098/rsta.2008.0089

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Biomedical science and its allied disciplines are entering a new era in which computational methods and technologies are poised to play a prevalent role in supporting collaborative investigation of the human body. Within Europe, this has its focus in the virtual physiological human (VPH), which is an evolving entity that has emerged from the EuroPhysiome initiative and the strategy for the EuroPhysiome (STEP) consortium. The VPH is intended to be a solution to common infrastructure needs for physiome projects across the globe, providing a unifying architecture that facilitates integration and prediction, ultimately creating a framework capable of describing Homo sapiens in silico. The routine reliance of the biomedical industry, biomedical research and clinical practice on information technology (IT) highlights the importance of a tailor-made and robust IT infrastructure, but numerous challenges need to be addressed if the VPH is to become a mature technological reality. Appropriate investment will reap considerable rewards, since it is anticipated that the VPH will influence all sectors of society, with implications predominantly for improved healthcare, improved competitiveness in industry and greater understanding of (patho) physiological processes. This paper considers issues pertinent to the development of the VPH, highlighted by the work of the STEP consortium.

引用

页码：2979 / 2999

页数：21

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