The macro-ethics of genomics to health: the Physiome Project

被引：4

作者：

Bassingthwaighte, JB ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

COMPTES RENDUS BIOLOGIES | 2003年 / 326卷 / 10-11期

关键词：

biological databases; computational systems biology; control of gene expression; ethics and society; metabolic engineering; pharmaceutics; physiome;

D O I：

10.1016/j.crvi.2003.09.006

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

Advances in pharmacology and genomics, and their intervention in human biology are beyond our abilities to understand their consequences. Therapeutic intervention in highly complex, non-linear, adaptive biological systems results in some unforeseen and undesirable consequences. To do the most good with the least harm, the information on biological systems should be gathered into databases, and into comprehensive quantitative models that can help to predict the long-range effects of proposed interventions. This is a societal or professional macro-ethical imperative. The Physiome Project helps to meet this imperative via databasing and creating models and tools for large-scale integration. (C) 2003 Academic des sciences. Published by Elsevier SAS. All rights reserved.

引用

页码：1105 / 1110

页数：6

共 11 条

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[2]

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[3]

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[4]

BASSINGTHWAIGHTE JB, 1995, ADV EXP MED BIOL, V382, P331