Sansalvamide: A new cytotoxic cyclic depsipeptide produced by a marine fungus of the genus Fusarium

被引：137

作者：

Belofsky, GN ^{[1
]}

Jensen, PR ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 15期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)00393-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new cyclic pentadepsipeptide, sansalvamide (1), has been isolated from organic extracts of the mycelium of a fungus of the genus Fusarium collected from the surface of the seagrass Halodule wrightii. The structure of 1 was determined through extensive analysis of 1D and 2D NMR data. Sansalvamide exhibited selective in vitro cytotoxicity toward COLO 205 colon and SK-MEL-2 melanoma cancer cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2913 / 2916

页数：4