Purpuracenin:: a new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenin from the seeds of Annona purpurea

被引：16

作者：

Chávez, D

Mata, R ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Dept Farmacia, Fac Quim, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Quim, Unidad Invest Plantas Med, Mexico City 04510, DF, Mexico

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 05期

关键词：

Annona purpurea; Annonaceae; annonaceous acetogenins; purpuracenin; annoglaucin;

D O I：

10.1016/S0031-9422(98)00553-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Purpuracenin, a novel cytotoxic acetogenin and annoglaucin, a known compound, were isolated from the seeds of Annona purpurea. Their structures were elucidated by a combination of chemical and spectral methods including MS and NMR spectral measurements. The absolute configurations of both compounds are presented. The new compound and annoglaucin exhibited potent cytotoxic activity in vitro against six human solid tumor cell lines. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：823 / 828

页数：6

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