Purpurediolin and purpurenin, two new cytotoxic adjacent bis-tetrahydrofuran annonaceous acetogenins from the seeds of Annona purpurea

被引：22

作者：

Chávez, D

Mata, R ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Inst Quim, Unidad Invest Plantas Med, Mexico City 04510, DF, Mexico

来源：

JOURNAL OF NATURAL PRODUCTS | 1998年 / 61卷 / 05期

关键词：

D O I：

10.1021/np970410+

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two novel cytotoxic acetogenins, purpurediolin (1) and purpurenin (2), were isolated from the seeds of Annona purpurea. Their structures were elucidated by a combination of chemical and spectral methods including MS and NMR measurements. In addition, six known acetogenins were obtained, namely, bullatacin, squamocin (annonin I), motrilin (squamocin C), annoglaucin, xylomatenin, and annonacin A. Compounds 1 and 2 exhibited potent; cytotoxic activity in vitro against six human solid tumor cell lines.

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页码：580 / 584

页数：5

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