Isostructural self-assembly of 2′-deoxyguanosine derivatives in aqueous and organic media

被引：44

作者：

Garcia-Arriaga, Marilyn ^{[1
]}

Hobley, Gerard ^{[1
]}

Rivera, Jose M. ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, Rio Piedras, PR 00931 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2008年 / 130卷 / 32期

关键词：

D O I：

10.1021/ja8039019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the self-assembly of a hydrophilic 8-(m-acetylphenyl)-2'-deoxyguanosine (mAG) derivative into a discrete and thermally stable hexadecameric supramolecule in aqueous media. We demonstrate that this hexadecamer is isostructural to the one formed by a related lipophilic derivative in organic media. This mAG moiety represents a rare example of a small-molecule recognition motif that is capable of assembling isostructurally and with high fidelity in both organic and aqueous media.

引用

页码：10492 / +

页数：3

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