Systemic oxidative stress and cognitive performance in the population-based EVA study

被引:56
作者
Berr, C [1 ]
Richard, MJ
Roussel, AM
Bonithon-Kopp, C
机构
[1] Hop La Pitie Salpetriere, INSERM U360, F-75651 Paris 13, France
[2] Univ J Fourier, Grp Rech & Etud Pathol Oxidat, F-38700 La Tronche, France
[3] Hop Broussais, INSERM U258, F-75674 Paris 14, France
关键词
antioxidant; carotenoids; cognitive performance; population-based study; free radicals;
D O I
10.1016/S0891-5849(97)00432-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aim of this study was to examine the relationships between cognitive functioning and blood levels of antioxidants and lipoperoxidation produces in an elderly population. In 1991-1992, 1389 volunteers (574 men and 815 women aged 59 to 71 years) were recruited from the general population. Levels of selenium, carotenoids, and thiobarbituric-reactive substances in plasma and of vitamin E, glutathione peroxidase, and Cu-Zn superoxide dismutase in red blood cells were measured. Cognitive functioning was assessed with various psychometric tests. We used logistic regression to estimate the risk of poor cognitive functioning (<25th percentile of the score distribution) associated with low values of each antioxidants (<25th percentile) including potential confounding factors. A low level of total carotenoids (<1.86 mu mol/l) was associated with poor cognitive performance in two tests assessing visual attention and logical reasoning: the Trail-Making Test part B [OR = 1.34 IC95% (0.99-1.81), p = .055] and the Digit Symbol Substitution from the WAIS-R [OR = 1.38 IC95% (1.02-1.89); p = .04]. Low levels of other antioxidants and high levels of thiobarbituric-reactive substances were not related to poor cognitive functioning. Results observed with plasma carotenoids are in accordance with previous data obtained mostly from dietary records. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:1202 / 1208
页数:7
相关论文
共 33 条
  • [1] SIMULTANEOUS DETERMINATION OF RETINOL, ALPHA-TOCOPHEROL AND BETA-CAROTENE IN SERUM BY ISOCRATIC HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    ARNAUD, J
    FORTIS, I
    BLACHIER, S
    KIA, D
    FAVIER, A
    [J]. JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1991, 572 (1-2): : 103 - 116
  • [2] AGING, ENERGY, AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISEASES
    BEAL, MF
    [J]. ANNALS OF NEUROLOGY, 1995, 38 (03) : 357 - 366
  • [3] THE IMPACT OF SELENIUM SUPPLEMENTATION ON MOOD
    BENTON, D
    COOK, R
    [J]. BIOLOGICAL PSYCHIATRY, 1991, 29 (11) : 1092 - 1098
  • [4] Early effect of ApoE-epsilon 4 allele on cognitive results in a group of highly performing subjects: The EVA study
    Berr, C
    Dufouil, C
    Brousseau, T
    Richard, F
    Amouyel, P
    Marceteau, E
    Alperovitch, A
    [J]. NEUROSCIENCE LETTERS, 1996, 218 (01) : 9 - 12
  • [5] BERR C, IN PRESS J VIT NUTR
  • [6] Combined effects of lipid peroxidation and antioxidant status on carotid atherosclerosis in a population aged 59-71 y: The EVA Study
    BonithonKopp, C
    Coudray, C
    Berr, C
    Touboul, PJ
    Feve, JM
    Favier, A
    Ducimetiere, P
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 65 (01) : 121 - 127
  • [7] Relation of intima-media thickness to atherosclerotic plaques in carotid arteries - The vascular aging (EVA) study
    BonithonKopp, C
    Touboul, PJ
    Berr, C
    Leroux, C
    Mainard, F
    Courbon, D
    Ducimetiere, P
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (02) : 310 - 316
  • [8] CEREBRAL WHITE-MATTER LESIONS, VASCULAR RISK-FACTORS, AND COGNITIVE FUNCTION IN A POPULATION-BASED STUDY - THE ROTTERDAM STUDY
    BRETELER, MMB
    VANSWIETEN, JC
    BOTS, ML
    GROBBEE, DE
    CLAUS, JJ
    VANDENHOUT, JHW
    VANHARSKAMP, F
    TANGHE, HLJ
    DEJONG, PTVM
    VANGIJN, J
    HOFMAN, A
    [J]. NEUROLOGY, 1994, 44 (07) : 1246 - 1252
  • [9] REVERSAL OF AGE-RELATED INCREASE IN BRAIN PROTEIN OXIDATION, DECREASE IN ENZYME-ACTIVITY, AND LOSS IN TEMPORAL AND SPATIAL MEMORY BY CHRONIC ADMINISTRATION OF THE SPIN-TRAPPING COMPOUND N-TERT-BUTYL-ALPHA-PHENYLNITRONE
    CARNEY, JM
    STARKEREED, PE
    OLIVER, CN
    LANDUM, RW
    CHENG, MS
    WU, JF
    FLOYD, RA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (09) : 3633 - 3636
  • [10] Peripheral antioxidant enzyme activities and selenium in elderly subjects and in dementia of Alzheimer's type - Place of the extracellular glutathione peroxidase
    CeballosPicot, I
    MeradBoudia, M
    Nicole, A
    Thevenin, M
    Hellier, G
    Legrain, S
    Berr, C
    [J]. FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (04) : 579 - 587