Single intracerebroventricular administration of amyloid-beta (25-35) peptide induces impairment in short-term rather than long-term memory in rats

被引：97

作者：

Stepanichev, MY ^{[1
]}

Moiseeva, YV ^{[1
]}

Lazareva, NA ^{[1
]}

Onufriev, MV ^{[1
]}

Gulyaeva, NV ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Higher Nervous Activ & Neurophysiol, Dept Funct Biochem Nervous Syst, Moscow 117485, Russia

来源：

BRAIN RESEARCH BULLETIN | 2003年 / 61卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

amyloid-beta (25-35) peptide; short-term memory; working memory; long-term memory; 8-arm radial maze; Y-maze; passive avoidance; social recognition;

D O I：

10.1016/S0361-9230(03)00118-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ample experimental evidence indicates that intracerebral injection or infusion of amyloid-beta peptides (Abeta) to rodents induces learning and memory impairments as well as neurodegeneration in brain areas related to cognitive function. In the present study, we assessed the effects of a single intracerebroventricular (i.c.v.) injection of aggregated Abeta fragment (25-35) at a dose of 15 nmol/rat on short-term and long-term memory in rats during the 6-month post-surgery period. The results demonstrate that Abeta(25-35)-induced memory impairments in spontaneous alternation behavior in a Y-maze at 17, 36, and 180 days after the surgery as well as in a social recognition task 110 days post-surgery. Abeta(25-35) also impaired spatial memory in an 8-arm radial maze, but did not influence performance of the step-down passive avoidance task. These results suggest that Abeta(25-35) preferably induces impairments of spatial and non-spatial short-term (working) memory rather than long-term memory in rats. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：197 / 205

页数：9

共 57 条

[1] ADMINISTRATION OF AMYLOID BETA-PEPTIDES INTO THE MEDIAL SEPTUM OF RATS DECREASES ACETYLCHOLINE-RELEASE FROM HIPPOCAMPUS IN-VIVO [J].