New procedures for the Julia-Colonna asymmetric epoxidation: synthesis of (+)-clausenamide

被引：78

作者：

Cappi, MW

Chen, WP

Flood, RW

Liao, YW

Roberts, SM ^{[1
]}

Skidmore, J

Smith, JA

Williamson, NM

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

[2] Second Mil Med Univ, Coll Pharm, Shanghai 200433, Peoples R China

[3] Univ Liverpool, Sch Biol Sci, Liverpool L69 7ZB, Merseyside, England

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 10期

关键词：

D O I：

10.1039/a801450g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The oxidation of chalcone 1 to optically active epoxide 2 [a precursor of (+)-clausenamide (+)-3] may be effected using a 15-mer or 20-mer of L-leucine bound to a PEG based support; poly-L-leucines of this type may be used as immobilised catalysts in a fixed-bed reactor.

引用

页码：1159 / 1160

页数：2

共 23 条

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