Is ISABA-1 customized for Acinetobacter?

被引：141

作者：

Segal, H

Garny, S

Elisha, BG

机构：

[1] Univ Cape Town, Inst Infect Dis & Mol Med, Div Med Microbiol, Med Sch UCT, ZA-7925 Cape Town, South Africa

[2] Groote Schuur Hosp, Natl Hlth Lab Serv, ZA-7925 Cape Town, South Africa

来源：

FEMS MICROBIOLOGY LETTERS | 2005年 / 243卷 / 02期

基金：

英国医学研究理事会;

关键词：

Acinetobacter; IS; promoters; sulphonamide resistance;

D O I：

10.1016/j.femsle.2005.01.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An insertion sequence (ISABA-1) was identified in Acinetobacter spp., but not in Enterobacteriacea, and Pseudomonas aeruginosa. Numerous copies of the IS were identified in Acinetobacter strains containing the element. In one of the Acinetobacter baumannii strains, ISABA-1 was identified adjacent to sulII and transcription of the resistance gene is presumed to be dependent on promoter sequences within the IS. Since the IS is adjacent to ampC and bla(OXA) in this A. baumannii strain, it may be that ISABA-1 plays an important role in the expression of antibiotic resistance genes in this genus. (C) 2005 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：425 / 429

页数：5

共 17 条

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