Tethered neuraminidase inhibitors that bind an influenza virus: A first step towards a diagnostic method for influenza

被引：17

作者：

McKimm-Breschkin, JL

Colman, PM

Jin, B

Krippner, GY

McDonald, M

Reece, PA

Tucker, SP

Waddington, L

Watson, KG

Wu, WY

机构：

[1] Biomol Res Inst, Parkville, Vic 3052, Australia

[2] Biota Holdings, Melbourne, Vic 3004, Australia

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 27期

关键词：

antiviral agents; glycoconjugates; hydrolases; influenza viruses; sialic acids;

D O I：

10.1002/anie.200250402

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Catching flu: The influenza virus neuraminidase inhibitor zanamivir (red) is functionalized at the 7-position to give derivatives that retain a high affinity for the enzyme. When conjugated to biotin (green) or onto microspheres, such derivatives can be used to capture or aggregate influenza virus particles.

引用

页码：3118 / 3121

页数：4

共 23 条

[1] Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain [J].