Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs

被引：168

作者：

Perry, EK

Kilford, L

Lees, AJ

Burn, DJ

Perry, RH

机构：

[1] Newcastle Gen Hosp, Wolfson Res Ctr, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[2] Newcastle Gen Hosp, Dept Neuropathol, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

[3] UCL, Inst Neurol, Sara Koe PSP Res Ctr, London, England

[4] Royal Free & UCL Med Sch, Reta Lila Weston Inst Neurol Studies, London, England

来源：

ANNALS OF NEUROLOGY | 2003年 / 54卷 / 02期

关键词：

D O I：

10.1002/ana.10639

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.

引用

页码：235 / 238

页数：4