Novel 6,12-disubstituted chrysene as potent anticancer agent: Synthesis, in vitro and in vivo study

被引：26

作者：

Banik, Bimal K. ^{[1
]}

Becker, Frederick F. ^{[2
]}

机构：

[1] Univ Texas Pan Amer, Dept Chem, Edinburg, TX 78539 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Mol Pathol, Unit 951, Houston, TX 77030 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 10期

关键词：

Substituted chrysenes; Anticancer agents; In vitro assay; In vivo test; POLYCYCLIC AROMATIC-COMPOUNDS; ANTITUMOR-ACTIVITY; BIOLOGICAL EVALUATION; DNA INTERCALATORS; ANTHRACENE-9,10-DIONES; DERIVATIVES; REDUCTION; BINDING; IMINES;

D O I：

10.1016/j.ejmech.2010.07.033

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

引用

页码：4687 / 4691

页数：5

共 34 条

[1]

ANTHRACENE-9,10-DIONES AS POTENTIAL ANTICANCER AGENTS - SYNTHESIS, DNA-BINDING, AND BIOLOGICAL STUDIES ON A SERIES OF 2,6-DISUBSTITUTED DERIVATIVES [J].

AGBANDJE, M ;

JENKINS, TC ;

MCKENNA, R ;

RESZKA, AP ;

NEIDLE, S .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (08) :1418-1429

[2]

(1-PYRENYLMETHYL)AMINO ALCOHOLS, A NEW CLASS OF ANTITUMOR DNA INTERCALATORS - DISCOVERY AND INITIAL AMINE SIDE-CHAIN STRUCTURE ACTIVITY STUDIES [J].

BAIR, KW ;

TUTTLE, RL ;

KNICK, VC ;

CORY, M ;

MCKEE, DD .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (09) :2385-2393

[3]

2-[(ARYLMETHYL)AMINO]-2-METHYL-1,3-PROPANEDIOL DNA INTERCALATORS - AN EXAMINATION OF THE EFFECTS OF AROMATIC RING VARIATION ON ANTITUMOR-ACTIVITY AND DNA-BINDING [J].

BAIR, KW ;

ANDREWS, CW ;

TUTTLE, RL ;

KNICK, VC ;

CORY, M ;

MCKEE, DD .

JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (07) :1983-1990

[4]

Banik B.K., 2005, ORG SYN, V81, P188

[5]

Synthesis, electrophilic substitution and structure-activity relationship studies of polycyclic aromatic compounds towards the development of anticancer agents [J].

Banik, BK ;

Becker, FF .

CURRENT MEDICINAL CHEMISTRY, 2001, 8 (12) :1513-1533

[6]

Samarium-induced iodine-catalyzed reduction of imines: synthesis of amine derivatives [J].

Banik, BK ;

Zegrocka, O ;

Banik, I ;

Hackfeld, L ;

Becker, FF .

TETRAHEDRON LETTERS, 1999, 40 (37) :6731-6734

[7]

Polycyclic aromatic compounds as anticancer agents: Structure-activity relationships of chrysene and pyrene derivatives [J].

Banik, BK ;

Becker, FF .

BIOORGANIC & MEDICINAL CHEMISTRY, 2001, 9 (03) :593-605

[8]

A facile reduction of aromatic nitro compounds to aromatic amines by samarium and iodine [J].

Banik, BK ;

Mukhopadhyay, C ;

Venkatraman, MS ;

Becker, FF .

TETRAHEDRON LETTERS, 1998, 39 (40) :7243-7246

[9]

Indium/ammonium chloride mediated selective reduction of aromatic nitro compounds: Practical synthesis of 6-aminochrysene [J].

Banik, BK ;

Suhendra, M ;

Banik, I ;

Becker, FF .

SYNTHETIC COMMUNICATIONS, 2000, 30 (20) :3745-3754

[10]

Stereoselective synthesis of β-lactams with polyaromatic imines:: Entry to new and novel anticancer agents [J].

Banik, I ;

Becker, FF ;

Banik, BK .

JOURNAL OF MEDICINAL CHEMISTRY, 2003, 46 (01) :12-15

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