Self-immolative dendrimers

被引：262

作者：

Amir, RJ ^{[1
]}

Pessah, N ^{[1
]}

Shamis, M ^{[1
]}

Shabat, D ^{[1
]}

机构：

[1] Tel Aviv Univ, Fac Exact Sci, Sch Chem, Dept Organ Chem, IL-69978 Tel Aviv, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 37期

关键词：

amides; dendrimers; dyes; fragmentation; rearrangement;

D O I：

10.1002/anie.200351962

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Docking the tails: The triggering of a single cleavage at the core of a new class of dendrimers (see, for example, the second generation dendron) results in a spontaneous chain fragmentation and the release all of the tail (reporter) units. Such dendrimers may be applied as a general platform for prodrugs or sensor molecules for enzymatic activity.

引用

页码：4494 / 4499

页数：6

共 17 条

[1] Polyester dendritic systems for drug delivery applications:: In vitro and in vivo evaluation [J].

De Jesús, OLP ;

Ihre, HR ;

Gagne, L ;

Fréchet, JMJ ;

Szoka, FC .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :453-461

[2]

Grinstaff MW, 2002, CHEM-EUR J, V8, P2838, DOI 10.1002/1521-3765(20020703)8:13<2838::AID-CHEM2838>3.0.CO

[3]

2-I

[4] Polyester dendritic systems for drug delivery applications:: Design, synthesis, and characterization [J].

Ihre, HR ;

De Jesüs, OLP ;

Szoka, FC ;

Fréchet, JMJ .

BIOCONJUGATE CHEMISTRY, 2002, 13 (03) :443-452

[5] Applications of dendrimers in bio-organic chemistry [J].

Kim, Y ;

Zimmerman, SC .

CURRENT OPINION IN CHEMICAL BIOLOGY, 1998, 2 (06) :733-742

[6] Synthesis of polyamidoamine dendrimers having poly(ethylene glycol) grafts and their ability to encapsulate anticancer drugs [J].

Kojima, C ;

Kono, K ;

Maruyama, K ;

Takagishi, T .

BIOCONJUGATE CHEMISTRY, 2000, 11 (06) :910-917

[7]

Lougerstay-Madec R, 1998, ANTI-CANCER DRUG DES, V13, P995

[8] Synthesis of self-immolative glucuronide spacers based on aminomethylcarbamate. Application to 5-fluorouracil prodrugs for antibody-directed enzyme prodrug therapy [J].

Madec-Lougerstay, R ;

Florent, JC ;

Monneret, C .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (10) :1369-1375

[9] Dendritic polymer macromolecular carriers for drug delivery [J].

Patri, AK ;

Majoros, IJ ;

Baker, JR .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (04) :466-471

[10] Synthesis and enzymatic degradation of dendrimers from (R)-3-hydroxy-butanoic acid and trimesic acid [J].

Seebach, D ;

Herrmann, GF ;

Lengweiler, UD ;

Bachmann, BM ;

Amrein, W .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (23-24) :2795-2797

← 1 2 →