Androgen excess down-regulates connexin43 in a human granulosa cell line

被引：40

作者：

Wu, Cheng-Hsuan ^{[2
,3
]}

Yang, Jyuer-Ger ^{[2
]}

Yang, Jiann-Jou ^{[4
]}

Lin, Yueh-Min ^{[5
]}

Tsai, Hong-Der ^{[2
]}

Lin, Ching-Yuang ^{[6
]}

Kuo, Pao-Lin ^{[1
]}

机构：

[1] Natl Cheng Kung Univ Hosp, Dept Obstet & Gynecol, Tainan 704, Taiwan

[2] Changhua Christian Hosp, Dept Obstet & Gynecol, Changhua, Taiwan

[3] Chung Shan Med Univ, Inst Med, Taichung, Taiwan

[4] Chung Shan Med Univ, Dept Biomed Sci, Taichung, Taiwan

[5] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan

[6] China Med Univ Hosp, China Med Univ Clin Immunol Ctr, Taichung 40402, Taiwan

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 07期

关键词：

Connexin43; gap junction intercellular communication; polycystic ovary syndrome; POLYCYSTIC-OVARY-SYNDROME; INTERCELLULAR COMMUNICATION; MESSENGER-RNA; GAP-JUNCTIONS; EXPRESSION; PROTEIN; FOLLICULOGENESIS; FLUTAMIDE; MOUSE; WOMEN;

D O I：

10.1016/j.fertnstert.2010.06.077

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

By use of a cell model, we found that high levels of androgen reduce connexin43 expression and impair gap junction intercellular communication between human granulosa cells through the androgen receptors. High levels of androgen may impair folliculogenesis and in turn lead to ovulatory dysfunction in polycystic ovary syndrome patients. (Fertil Steril (R) 2010;94:2938-41. (c) 2010 by American Society for Reproductive Medicine.)

引用

页码：2938 / 2941

页数：4

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