E2F-1 induced apoptosis

被引：123

作者：

Phillips, AC ^{[1
]}

Vousden, KH ^{[1
]}

机构：

[1] NCI, Regulat Cell Growth Lab, FCRDC, Frederick, MD 21702 USA

来源：

APOPTOSIS | 2001年 / 6卷 / 03期

关键词：

apoptosis; cell cycle; E2F1; p53;

D O I：

10.1023/A:1011332625740

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the E2F family of transcription factors play an important role in regulating the cell cycle, and their activity is often perturbed during the development of human malignancies. More recent work has shown that E2F-1 regulates apoptosis as well as proliferation, in part by stabilizing the p53 tumor suppressor, an important mediator of apoptosis. This has led to the suggestion that E2F-1 may function as a tumor surveillance mechanism, detecting aberrant proliferation and engaging apoptotic pathways to protect the organism from developing tumors.

引用

页码：173 / 182

页数：10