Mouse Tumor Biology (MTB): a database of mouse models for human cancer

被引：40

作者：

Bult, Carol J. ^{[1
]}

Krupke, Debra M. ^{[1
]}

Begley, Dale A. ^{[1
]}

Richardson, Joel E. ^{[1
]}

Neuhauser, Steven B. ^{[1
]}

Sundberg, John P. ^{[1
]}

Eppig, Janan T. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

GENETICALLY-ENGINEERED MICE; TRANSGENIC MICE; PATIENT; RAS; RECOMMENDATIONS; CLASSIFICATION; SUSCEPTIBILITY; PERSPECTIVES; XENOGRAFTS; RESOURCES;

D O I：

10.1093/nar/gku987

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mouse Tumor Biology (http://tumor.informatics.jax.org) database is a unique online compendium of mouse models for human cancer. MTB provides online access to expertly curated information on diverse mouse models for human cancer and interfaces for searching and visualizing data associated with these models. The information in MTB is designed to facilitate the selection of strains for cancer research and is a platform for mining data on tumor development and patterns of metastases. MTB curators acquire data through manual curation of peer-reviewed scientific literature and from direct submissions by researchers. Data in MTB are also obtained from other bioinformatics resources including PathBase, the Gene Expression Omnibus and ArrayExpress. Recent enhancements to MTB improve the association between mouse models and human genes commonly mutated in a variety of cancers as identified in large-scale cancer genomics studies, provide new interfaces for exploring regions of the mouse genome associated with cancer phenotypes and incorporate data and information related to Patient-Derived Xenograft models of human cancers.

引用

页码：D818 / D824

页数：7

共 46 条

[1] K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder
Ahmad, Imran
Singh, Lukram Babloo
Foth, Mona
Morris, Carol-Ann
Taketo, Makoto Mark
Wu, Xue-Ru
Leung, Hing Y.
Sansom, Owen J.
Iwata, Tomoko
[J]. DISEASE MODELS & MECHANISMS, 2011, 4 (04) : 548 - 555
[2] NCBI GEO: archive for functional genomics data sets-update
Barrett, Tanya
Wilhite, Stephen E.
Ledoux, Pierre
Evangelista, Carlos
Kim, Irene F.
Tomashevsky, Maxim
Marshall, Kimberly A.
Phillippy, Katherine H.
Sherman, Patti M.
Holko, Michelle
Yefanov, Andrey
Lee, Hyeseung
Zhang, Naigong
Robertson, Cynthia L.
Serova, Nadezhda
Davis, Sean
Soboleva, Alexandra
[J]. NUCLEIC ACIDS RESEARCH, 2013, 41 (D1) : D991 - D995
[3] Mouse Tumor Biology Database (MTB): status update and future directions
Begley, Dale A.
Krupke, Debra M.
Vincent, Matthew J.
Sundberg, John P.
Bult, Carol J.
Eppig, Janan T.
[J]. NUCLEIC ACIDS RESEARCH, 2007, 35 : D638 - D642
[4] The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse
Blake, Judith A.
Bult, Carol J.
Eppig, Janan T.
Kadin, James A.
Richardson, Joel E.
[J]. NUCLEIC ACIDS RESEARCH, 2014, 42 (D1) : D810 - D817
[5] The mammalian gene function resource: the international knockout mouse consortium
Bradley, Allan
Anastassiadis, Konstantinos
Ayadi, Abdelkader
Battey, James F.
Bell, Cindy
Birling, Marie-Christine
Bottomley, Joanna
Brown, Steve D.
Buerger, Antje
Bult, Carol J.
Bushell, Wendy
Collins, Francis S.
Desaintes, Christian
Doe, Brendan
Economides, Aris
Eppig, Janan T.
Finnell, Richard H.
Fletcher, Colin
Fray, Martin
Frendewey, David
Friedel, Roland H.
Grosveld, Frank G.
Hansen, Jens
Herault, Yann
Hicks, Geoffrey
Hoerlein, Andreas
Houghton, Richard
de Angelis, Martin Hrabe
Huylebroeck, Danny
Iyer, Vivek
de Jong, Pieter J.
Kadin, James A.
Kaloff, Cornelia
Kennedy, Karen
Koutsourakis, Manousos
Lloyd, K. C. Kent
Marschall, Susan
Mason, Jeremy
McKerlie, Colin
McLeod, Michael P.
von Melchner, Harald
Moore, Mark
Mujica, Alejandro O.
Nagy, Andras
Nefedov, Mikhail
Nutter, Lauryl M.
Pavlovic, Guillaume
Peterson, Jane L.
Pollock, Jonathan
Ramirez-Solis, Ramiro
[J]. MAMMALIAN GENOME, 2012, 23 (9-10) : 580 - 586
[6] Humanized mouse models to study human diseases
Brehm, Michael A.
Shultz, Leonard D.
Greiner, Dale L.
[J]. CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2010, 17 (02) : 120 - 125
[7] The International Mouse Phenotyping Consortium: past and future perspectives on mouse phenotyping
Brown, Steve D. M.
Moore, Mark W.
[J]. MAMMALIAN GENOME, 2012, 23 (9-10) : 632 - 640
[8] Electronic access to mouse tumor data: the mouse tumor biology database (MTB) project
Bult, CJ
Krupke, DM
Eppig, JT
[J]. NUCLEIC ACIDS RESEARCH, 1999, 27 (01) : 99 - 105
[9] The mammary pathology of genetically engineered mice: the consensus report and recommendations from the Annapolis meeting
Cardiff, RD
Anver, MR
Gusterson, BA
Hennighausen, L
Jensen, RA
Merino, MJ
Rehm, S
Russo, J
Tavassoli, FA
Wakefield, LM
Ward, JM
Green, JE
[J]. ONCOGENE, 2000, 19 (08) : 968 - 988
[10] Cancer susceptibility in the mouse: Genetics, biology and implications for human cancer
Demant, P
[J]. NATURE REVIEWS GENETICS, 2003, 4 (09) : 721 - 734

← 1 2 3 4 5 →